I'm close to either of my parents and grandparents (as long as I steer clear of religious talk beyond the surface level, because of differences between my beliefs and their mainline Baptist ideas), but I'm quite distant from my brother (who still lives with us as a NEET despite being in his early twenties) because of how far he is from my view of things. He consistently verges on atheism and uses Christianity only as a dialectical crutch for him to defend his moral and political viewpoints with (whenever it goes with them, that is; "'love thy neighbor' means aid for Ukraine!"), and I despise that.
He is a lousy leftist bedroom goblin and he munches on prescription drugs for all of his comfort. He munched on too many of them last year after a hippie girlfriend he met when he still had a retail job broke up with him, and that ended up costing our family a bunch of money in hospital bills. I had to be the one to find his shit-smelling, unconscious self on the floor of his bedroom on the night of that overdose, too. Jesus once said that "whoever loves God must also love his brother," and, well, fuck, if that isn't a difficult task then I don't know what is.